Vitamin E, 5-lipoxygenase and oxidative stress in haemodialysis patients: facts, not fancies.

serum urea and creatinine levels. He had complained of painful red eye and decreased vision in both eyes for 2 months. There was no history of ingestion of any drugs. There was no significant past medical history. Physical examination was unremarkable except for the bilateral red eye. Laboratory findings were as followed; urea 51mg/dl, serum creatinine 1.6mg/dl. Other biochemical and haematological tests were normal. Urinalysis showed a pH of 6, specific gravity 1032, glucose positive, protein 34mg/dl, 15–20 red blood cells/high-power field. Twenty four hour urinary protein was 680mg/day and estimated creatinine clearance was 63.5ml/min. Serum glucose levels, glycosylated haemoglobin, immunoglobulin levels, complement fractions C3 and C4 and urinary elimination of b2-microglobulin were normal. Serological tests for the infectious and noninfectious causes of AIN were negative. An ophthalmological examination revealed bilateral non-granulomatous anterior and posterior uveitis with posterior synechiae and posterior subcapsular cataract on left eye. Abdominal ultrasonography was normal except increased parenchymal echo patterns in both kidneys. In light microscopy of a kidney biopsy, mild mesengial proliferation and a moderate mononuclear cell infiltration in the interstitium were observed. Amyloid, IgA, Ig3G, IgM, C3, C4 and fibrin deposits were not detected and a diagnosis of AIN was made. The presence of unilateral uveitis confirmed the diagnosis of TINU. The patient was treated with 1mg/kg/day oral prednisone and topical corticosteroids. Six weeks after therapy, 24 h urinary protein and creatinine levels became 180mg/day and 1.1mg/dl respectively, and the uveitis improved.